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PKG Substrate
CAS No. 81187-14-6
PKG Substrate( —— )
Catalog No. M30485 CAS No. 81187-14-6
PKG Substrate is a selective substrate for cGMP-dependent protein kinase (PKG).PKG Substrate is a selective substrate for protein kinase G (PKG) with a strong preference for PKG Iα (Km = 59 μM) over PKG II (Km = 305 μM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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| 200MG | Get Quote | Get Quote |
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Biological Information
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Product NamePKG Substrate
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NoteResearch use only, not for human use.
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Brief DescriptionPKG Substrate is a selective substrate for cGMP-dependent protein kinase (PKG).PKG Substrate is a selective substrate for protein kinase G (PKG) with a strong preference for PKG Iα (Km = 59 μM) over PKG II (Km = 305 μM).
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DescriptionPKG Substrate is a selective substrate for cGMP-dependent protein kinase (PKG).PKG Substrate is a selective substrate for protein kinase G (PKG) with a strong preference for PKG Iα (Km = 59 μM) over PKG II (Km = 305 μM). (In Vitro):Incorporation of [33P]ATP into the synthetic peptide PKG substrate RKRSRAE is measured. N6-benzyl-ATP inhibits kinase activity of PKG Iα gatekeeper mutants but not WT. The serotonin transporter (SERT) is responsible for reuptake of serotonin (5-hydroxytryptamine) after its exocytotic release from neurons. SERT is regulated by several processes, including a cyclic GMP signaling pathway involving nitric oxide synthase, guanylyl cyclase, and PKG.
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In VitroIncorporation of [33P]ATP into the synthetic peptide PKG substrate RKRSRAE is measured. N6-benzyl-ATP inhibits kinase activity of PKG Iα gatekeeper mutants but not WT. The serotonin transporter (SERT) is responsible for reuptake of serotonin (5-hydroxytryptamine) after its exocytotic release from neurons. SERT is regulated by several processes, including a cyclic GMP signaling pathway involving nitric oxide synthase, guanylyl cyclase, and PKG.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorPKG
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Research Area——
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Indication——
Chemical Information
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CAS Number81187-14-6
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Formula Weight902.01
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Molecular FormulaC35H67N17O11
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Purity>98% (HPLC)
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SolubilityIn Vitro:?H2O : 100 mg/mL (110.86 mM)
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SMILES——
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Chemical NameSequence:Arg-Lys-Arg-Ser-Arg-Ala-Glu
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
Wong A, et al. Cyclic GMP-dependent stimulation of serotonin transport does not involve direct transporter phosphorylation by cGMP-dependent protein kinase. J Biol Chem. 2012 Oct 19;287(43):36051-8.
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